HDN primarily involves destruction of which fetal cells due to maternal antibodies?

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Multiple Choice

HDN primarily involves destruction of which fetal cells due to maternal antibodies?

HDN occurs when maternal antibodies cross the placenta and bind antigens on fetal red blood cells, leading to their destruction. The classic trigger is anti-D in Rh incompatibility, where fetal RBCs are hemolyzed by antibody-mediated mechanisms, causing fetal anemia and potential hyperbilirubinemia after birth. This process targets red blood cells specifically, not platelets, white blood cells, or neurons, which is why the destruction of fetal red blood cells is the correct concept.

HDN occurs when maternal antibodies cross the placenta and bind antigens on fetal red blood cells, leading to their destruction. The classic trigger is anti-D in Rh incompatibility, where fetal RBCs are hemolyzed by antibody-mediated mechanisms, causing fetal anemia and potential hyperbilirubinemia after birth. This process targets red blood cells specifically, not platelets, white blood cells, or neurons, which is why the destruction of fetal red blood cells is the correct concept.

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