In carbaminohemoglobin, carbon dioxide attaches to which part of the hemoglobin molecule?

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Multiple Choice

In carbaminohemoglobin, carbon dioxide attaches to which part of the hemoglobin molecule?

In carbaminohemoglobin, carbon dioxide binds to the protein portion of hemoglobin, specifically the amino-terminal ends of the globin chains (the alpha and beta chains). This binding occurs on the globin, not at the heme iron or the oxygen-binding site, and not at disulfide bonds. The CO2 forms a carbamate with these terminal amino groups, a reversible attachment that helps carry CO2 from tissues to the lungs and contributes to the way hemoglobin’s affinity for O2 changes with its own oxygenation state.

In carbaminohemoglobin, carbon dioxide binds to the protein portion of hemoglobin, specifically the amino-terminal ends of the globin chains (the alpha and beta chains). This binding occurs on the globin, not at the heme iron or the oxygen-binding site, and not at disulfide bonds. The CO2 forms a carbamate with these terminal amino groups, a reversible attachment that helps carry CO2 from tissues to the lungs and contributes to the way hemoglobin’s affinity for O2 changes with its own oxygenation state.

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