What occurs to RBCs if there is a transfusion reaction?

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Multiple Choice

What occurs to RBCs if there is a transfusion reaction?

The main idea is that an immune reaction against donor RBCs causes them to clump together and often rupture. In a transfusion reaction, antibodies in the recipient bind to antigens on donor red blood cells (for example, ABO antigens). This binding cross-links cells, causing agglutination (clumping). This antibody-coated surface also activates complement, which can lyse the red blood cells, leading to hemolysis. Remember, red blood cells don’t divide or become more flexible in this situation; their hallmark behavior in a transfusion reaction is agglutination with possible hemolysis.

The main idea is that an immune reaction against donor RBCs causes them to clump together and often rupture. In a transfusion reaction, antibodies in the recipient bind to antigens on donor red blood cells (for example, ABO antigens). This binding cross-links cells, causing agglutination (clumping). This antibody-coated surface also activates complement, which can lyse the red blood cells, leading to hemolysis. Remember, red blood cells don’t divide or become more flexible in this situation; their hallmark behavior in a transfusion reaction is agglutination with possible hemolysis.

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