What region is located between the two pleural cavities where the heart is positioned?

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The central compartment of the thoracic cavity, the mediastinum, is the region between the two pleural cavities. The lungs occupy the pleural spaces on either side, while the heart sits inside the mediastinum, enclosed by the pericardial cavity within that central space. So the heart is located in the mediastinum, not in either pleural cavity.