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Multiple Choice

Which organ synthesizes and releases 90% of plasma proteins?

The organ responsible for synthesizing and releasing the majority of plasma proteins is the liver. Hepatocytes produce albumin, which is the most abundant plasma protein and helps maintain blood osmotic (oncotic) pressure and transport many substances. The liver also makes most of the clotting factors and other important plasma proteins like transferrin and various complement proteins. Because these proteins come mainly from the liver, about 90% of plasma proteins originate there. Other organs—such as the spleen, which is involved in immune function and red blood cell turnover, or the heart—do not contribute the bulk of plasma proteins.

The organ responsible for synthesizing and releasing the majority of plasma proteins is the liver. Hepatocytes produce albumin, which is the most abundant plasma protein and helps maintain blood osmotic (oncotic) pressure and transport many substances. The liver also makes most of the clotting factors and other important plasma proteins like transferrin and various complement proteins. Because these proteins come mainly from the liver, about 90% of plasma proteins originate there. Other organs—such as the spleen, which is involved in immune function and red blood cell turnover, or the heart—do not contribute the bulk of plasma proteins.